Answers to common questions about Xultophy® 100/3.6

About Xultophy® 100/3.6

Xultophy® 100/3.6 is an injectable medicine for adults with type 2 diabetes.

Xultophy® 100/3.6 is not for use in people with type 1 diabetes or people with diabetic ketoacidosis (increased ketones in the blood or urine).



ZUL-to-fye is the correct pronunciation of Xultophy® 100/3.6.

The 100/3.6 means that Xultophy® 100/3.6 is made up of 100 units/mL of insulin degludec and 3.6 mg/mL of liraglutide.

You can take Xultophy® 100/3.6 at any time of the day, but you should take it at the same time each day.

If you miss a dose, take that dose at your next regular dosing time. Do not take an extra dose or increase the dose to make up for the one you missed.

Tell your health care provider about all medicines you take, including prescription and nonprescription medicines, vitamins, and herbal supplements.

Other medicines may interact with Xultophy® 100/3.6. See the Prescribing Information for more details.

Xultophy® 100/3.6 is not recommended for use in combination with any other product containing liraglutide or another GLP-1 receptor agonist. It is not known if Xultophy® 100/3.6 can be used with mealtime insulin.

Other medicines also may interact with Xultophy® 100/3.6. See the Prescribing Information for more details.

Your health care provider will give you your starting dose of Xultophy® 100/3.6 along with your blood sugar target range and show you how to adjust your dose based on your blood sugar readings. 

Use Xultophy® 100/3.6 exactly how your health care provider instructed.

Xultophy® 100/3.6 is taken once daily, at the same time each day.

Your dose may change depending on your daily blood sugar levels.

Your health care provider will advise you on how to adjust your Xultophy® 100/3.6 dose based on your daily blood sugar readings.

Checking and tracking your blood sugar lets you and your health care provider know if your current treatment is working. 

Xultophy® 100/3.6 is approved for adults with type 2 diabetes.

The Xultophy® 100/3.6 pen is available from pharmacies in packs of 5. Each pen contains 300 units of Xultophy® 100/3.6.

About the Xultophy® 100/3.6 pen

Xultophy® 100/3.6 comes in a prefilled pen with no push-button extension. Doses can be adjusted in 1-unit increments.

The Xultophy® 100/3.6 pen can deliver 10 to 50 units in a single injection. Doses can be adjusted in 1-unit increments.

Other prefilled injection pens have a push button that extends when the dose is dialed up. The Xultophy® 100/3.6 pen has a spring-loaded mechanism that allows the push button to stay in place at any dose.

The Xultophy® 100/3.6 pen is compatible with universal fit needles. We recommend NovoTwist®, NovoFine®, and NovoFine® Plus needles, including NovoFine® Autocover®.

Your Xultophy® 100/3.6 pen can go for up to 3 weeks without needing to put it in a cooler or refrigerator.

Once in use, the Xultophy® 100/3.6 pen can be stored at room temperature (59oF to 86oF) or refrigerated at 36oF to 46oF for up to 21 days.

Used needles and any empty Xultophy® 100/3.6 pens should be discarded in a sharps container or some type of hard plastic or metal container with a tight-fitting, puncture-resistant lid, such as an empty detergent bottle. Disposal requirements may vary locally. Check with your health care provider about the right way to throw away used needles.

Visit NovoCare.com to find out how to request a sharps disposal container.

If you have any additional questions, ask your health care provider or call Novo Nordisk at 1-866-696-4086.

Xultophy® 100/3.6 support

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Novo Nordisk partners with real adults to share real stories about life with diabetes. Please visit ShareMyDiabetesStory.com if you are an adult with type 2 diabetes and use Xultophy® 100/3.6 as a part of your diabetes care plan for blood sugar control and want to share your story to inspire others.

What is Xultophy® 100/3.6 (insulin degludec and liraglutide injection) 100 units/mL and 3.6 mg/mL?

Xultophy® 100/3.6 is an injectable prescription medicine that contains 2 diabetes medicines, insulin degludec, 100 units/mL, and liraglutide, 3.6 mg/mL. Xultophy® 100/3.6 should be used along with diet and exercise to lower blood sugar (glucose) in adults with type 2 diabetes mellitus.

  • Xultophy® 100/3.6 is not recommended as the first choice of medicine for treating diabetes.
  • Xultophy® 100/3.6 is not recommended for use in combination with any other product containing liraglutide or another glucagon like peptide 1 receptor agonist (GLP-1 RA).
  • Xultophy® 100/3.6 is not for use in people with type 1 diabetes or people with diabetic ketoacidosis (increased ketones in the blood or urine).
  • It is not known if Xultophy® 100/3.6 can be used with mealtime insulin.
  • It is not known if Xultophy® 100/3.6 is safe and effective for use in children.

Xultophy® 100/3.6 Important Safety Information

What is the most important information I should know about Xultophy® 100/3.6?

Xultophy® 100/3.6 may cause serious side effects, including:

  • Possible thyroid tumors, including cancer. Tell your health care provider if you get a lump or swelling in your neck, hoarseness, trouble swallowing, or shortness of breath. These may be symptoms of thyroid cancer. In studies with rats and mice, liraglutide, one of the components of Xultophy® 100/3.6, and medicines that work like liraglutide caused thyroid tumors, including thyroid cancer. It is not known if Xultophy® 100/3.6 will cause thyroid tumors or a type of thyroid cancer called medullary thyroid carcinoma (MTC) in people.

Who should not use Xultophy® 100/3.6?

Do not use Xultophy® 100/3.6 if:

  • you or any of your family have ever had MTC or if you have an endocrine system condition called Multiple Endocrine Neoplasia syndrome type 2 (MEN 2).
  • you are having an episode of low blood sugar or if you are allergic to insulin degludec, liraglutide, or any of the ingredients in Xultophy® 100/3.6.

What should I tell my health care provider before using Xultophy® 100/3.6?

Tell your health care provider about all your medical conditions, including if you:

  • have or have had problems with your pancreas, kidneys, or liver.
  • have heart failure or other heart problems. If you have heart failure, it may get worse while you take TZDs (thiazolidinediones) with Xultophy® 100/3.6.
  • have severe problems with your stomach, such as slowed emptying of your stomach (gastroparesis) or problems with digesting food.
  • are taking certain medicines called GLP-1 RA, or have had an allergic reaction to a GLP-1 RA.
  • are pregnant or breastfeeding or plan to become pregnant or breastfeed. It is not known if Xultophy® 100/3.6 passes into your breast milk.

Tell your health care provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Before using Xultophy® 100/3.6, talk to your health care provider about low blood sugar and how to manage it.

How should I use Xultophy® 100/3.6?

  • Read the Instructions for Use and take Xultophy® 100/3.6 exactly as your health care provider tells you.
  • Do not change your dosing schedule without first talking to your health care provider.
  • Do not inject Xultophy® 100/3.6 into a muscle or vein or use in an insulin infusion pump.
  • Use Xultophy® 100/3.6 at the same time each day with or without food. Do not take more than 50 units of Xultophy® 100/3.6 each day.
  • Check the Pen label each time you give your injection to make sure you are using the correct medicine.
  • Change (rotate) your injection sites within the area you choose with each injection to reduce your risk of getting lipodystrophy (pits in skin or thickened skin) and localized cutaneous amyloidosis (skin with lumps) at the injection sites.
    • Do not use the exact same spot for each injection.
    • Do not inject where the skin has pits, is thickened, or has lumps.
    • Do not inject where the skin is tender, bruised, scaly or hard, or into scars or damaged skin.
  • Do not share your Xultophy® 100/3.6 pen with other people, even if the needle has been changed. You may give other people a serious infection, or get a serious infection from them.
  • Check your blood sugar levels. Ask your health care provider what your blood sugar levels should be and when you should check them.

Your dose of Xultophy® 100/3.6 may need to change because of change in level of physical activity or exercise, weight gain or loss, increased stress, illness, change in diet, or other medicines you take.

What should I avoid while taking Xultophy® 100/3.6?

  • Do not drive or operate heavy machinery, until you know how Xultophy® 100/3.6 affects you. Do not drink alcohol or use prescription or over-the-counter medicines that contain alcohol.

What are the possible side effects of Xultophy® 100/3.6?

Xultophy® 100/3.6 may cause serious side effects that can be life-threatening, including:

  • inflammation of your pancreas (pancreatitis). Stop using Xultophy® 100/3.6 and call your health care provider right away if you have severe pain in your stomach area (abdomen) that will not go away, with or without vomiting. You may feel the pain from your abdomen to your back.
  • low blood sugar (hypoglycemia). Your risk for getting low blood sugar may be higher if you use Xultophy® 100/3.6 with another medication that can cause low blood sugar. Signs and symptoms of low blood sugar may include: shakiness, irritability, fast heartbeat, dizziness, weakness, sweating, confusion, drowsiness, hunger, headache, and feeling jittery.
  • kidney problems (kidney failure). Worsening of kidney failure and sudden kidney failure have happened in people with kidney problems and in people without kidney problems, who have taken liraglutide, one of the ingredients in Xultophy® 100/3.6. Diarrhea, nausea, and vomiting may cause a loss of fluids (dehydration) which may cause kidney problems to get worse. Tell your health care provider if you have diarrhea, nausea, or vomiting. Drink plenty of fluids to help reduce your risk of dehydration during treatment with Xultophy® 100/3.6.
  • serious allergic reactions. Stop using Xultophy® 100/3.6 and get medical help right away if you have any symptoms of a serious allergic reaction, including swelling of your face, lips, tongue or throat, problems breathing or swallowing, severe rash or itching, fainting or feeling dizzy, or a fast heartbeat.
  • gallbladder problems. Gallbladder problems have happened in some people who take liraglutide, an ingredient in Xultophy® 100/3.6. Tell your health care provider right away if you get symptoms of gallbladder problems including pain in the right or middle upper stomach area, fever, nausea and vomiting, or your skin or the white part of your eyes turn yellow.  
  • low potassium in your blood (hypokalemia).
  • heart failure.  Taking certain diabetes medicines called TZDs with Xultophy® 100/3.6 may cause heart failure in some people. This can happen even if you have never had heart failure or heart problems. If you already have heart failure, it may get worse while you take TZDs with Xultophy® 100/3.6. Tell your health care provider if you have any new or worse symptoms of heart failure, including shortness of breath, tiredness, swelling of your ankles or feet, and sudden weight gain.

The most common side effects of Xultophy® 100/3.6 may include stuffy or runny nose, sore throat, headache, nausea, diarrhea, increased blood levels of lipase, and upper respiratory tract infection.

Please see full Prescribing Information and Medication Guide for Xultophy® 100/3.6.

Xultophy® 100/3.6 is a prescription medication.

Look up your cost at MyXultophy10036Cost.com.

You are encouraged to report negative side effects of prescription drugs to the FDA.
Visit www.fda.gov/medwatch or call 1‑800-FDA-1088.

If you need assistance with prescription costs, help may be available. Visit www.pparx.org or call 1‑888-4PPA-NOW.

Talk to your health care provider about your diabetes management plan, including diet and exercise.